Clinical Pharmacology
This seminar covers key pharmacokinetic and pharmacodynamic principles relevant to the development and use of veterinary and human medicinal products. It explains how active substances behave in the body and which factors determine their effects, efficacy and tolerability.
Seminar content
- Pharmacokinetics: release, absorption, distribution, metabolism and elimination
- Bioavailability and key pharmacokinetic parameters
- Pharmacodynamics: mechanisms of action and receptors
- Agonism and antagonism
- Dose-response relationships and endpoints
- Therapeutic window
- Adverse effects and interactions
- Tolerance and changes in drug response
- Interpretation and analysis of clinical studies
Pharmacokinetics and pharmacodynamics in drug development
Pharmacokinetics describes what the body does to a drug, from its release and absorption to its distribution, metabolism and elimination. These processes largely determine the concentration and duration of the drug's effects.
Pharmacodynamics describes what a drug does to the body. This includes mechanisms of action, dose-response relationships, therapeutic effects, adverse effects and interactions.
This seminar gives you a practical understanding of the relationships between dose, drug concentration and clinical effect. You will learn to interpret pharmacokinetic and pharmacodynamic results and understand their relevance to drug development, clinical trials and treatment.